celecoxib and celecoxib, preferably from (rac)-tramadolHCl and celecoxib. better Pharmacokinetic/Pharmacodynamic (PKPD) including also a better
En una realización preferida del co-cristal con una relación molecular entre tramadol (o (rac)-tramadolHCl), paracetamol y H2O de 1:1:1 según la invención, el
by C Almansa 2024 Cited by 146As in rac-tramadolHCl, the structure of ctc contains both enantiomers of tramadol in a 1:1 ratio. The hydrogen bonding scheme and a view of
The results showed an increase exposure of celecoxib when the co-crystal (rac)-tramadolHCl-celecoxib was administered compared to celecoxib alone and to the
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Una composición farmacéutica que comprende una combinación de (rac)-tramadolHCl y celecoxib o su sal ohidrato farmacéuticamente aceptable, en la que la
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