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FAQs About Using Prednisone to Cough Up Mucus Does Prednisone Help with a Cough and Phlegm? Prednisone can help reduce inflammation in the respiratory tract, which may alleviate a cough associated with conditions like asthma or COPD. However, it does not directly target the production or expulsion of phlegm, as it is not a mucolytic agent.

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