Elderly: The elderly has an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation which may be
Do not use Morphine Sulfate Injection while you are breastfeeding as morphine Use in the elderly: Morphine doses need to be reduced in elderly patients.
side effects and whenever morphine therapy is being initiated Morphine should be administered with caution and in reduced dosages to elderly
Selected adverse drug reactions/Precautions unique to morphine: Active Elderly, cachectic, or debilitated patients: use with extreme caution due to
Oral Morphine: Reduce morphine dose in the frail, elderly, those with low body weight and those with renal or hepatic impairment. Morphine has active
Morphine is substantially excreted by the kidney; risk of adverse reactions may be greater in patients with impaired renal function, and elderly patients are more likely to have decreased renal function. Hepatic Impairment. Morphine pharmacokinetics are significantly altered in patients with cirrhosis.
by O Linares 2024Our results suggest that reduced morphine CL in the elderly is due, in part, to an age-related reduction in morphine's Vd in the elderly.
2 - Pharmacokinetics of morphine and oxycodone in frail elderly undergoing cardiac s . Intervention. Keyword : Frail, Morphine, Oxycodon
effect on respiration, caution is necessary when giving morphine to the elderly If signs and symptoms suggestive of these skin reactions appear, morphine
Regards, Jack