The cumulative exposure of EXPAREL in these studies is well in excess of the proposed maximum single-dose exposure that is intended in humans.
The maximum dosage of Exparel for adults is ~266 mg, but the maximum mg/kg dosing limit is unknown. The role of Intralipid (ILP, 20%) for
Recommended Dosing in Adults. Local Analgesia via Infiltration. The recommended dose of EXPAREL for local infiltration in adults is up to a maximum dose of.
This recommended maximum dose is 266 mg. If also administering bupivacaine, it is recommended not to exceed a ratio of milligram dose of bupivacaine to exparel
The maximum recommended dose of Exparel as a local analgesic is 266 mg (20 mL). And the maximum recommended dose of Exparel as a nerve block is 133 mg (10 mL).
Single dose of EXPAREL 4 mg/kg (not to exceed a maximum recommended dose of EXPAREL for local infiltration in adults is up to a maximum dose of 266 . Clinical Review Erin L. Zenilman, M.D.
EXPAREL is intended for single-dose infiltration only. EXPAREL should be administered with a 25 gauge or larger bore needle. The maximum dosage of EXPAREL
The maximum recommended dose of Exparel as a local analgesic is 266 mg (20 mL). And the maximum recommended dose of Exparel as a nerve block is 133 mg (10 mL).
The maximum dosage of Exparel for local pain management is 266 mg as a one-time single dose.
That said, keep up the story-telling. I'll be watching for part 2.