Fosphenytoin vs phenytoin

Phenytoin vs Fosphenytoin The efficacy of phenytoin and fosphenytoin for time to seizure cessation are comparable, however there are theoretical reasons why fosphenytoin might be preferred: Phenytoin and fosphenytoin have sodium channel blockade effects, which is similar to the mechanism of action of certain toxidromes such as TCA and cocaine

phenytoin equivalents (PE) (1mg PE Fosphenytoin = 1 mg IV phenytoin); 42. Phenytoin vs Fosphenytoin Phenytoin Fosphenytoin Vehicle Propylene

by M Madhiyazhagan 2024Department comparing phenytoin versus fosphenytoin protocol over of seizure with phenytoin compared to the fosphenytoin arm (17.7% vs.

Differences between fosphenytoin and phenytoin are primarily due to fosphenytoin being more water soluble. Fosphenytoin versus Phenytoin:

Dose equivalence and conversion for fosphenytoin sodium Doses are expressed as phenytoin sodium equivalent (PE); fosphenytoin sodium 1.5 mg ≡ phenytoin sodium

Fosphenytoin displaces phenytoin from binding sites. In the presence of fosphenytoin, the fraction of unbound phenytoin increases; 70% of

Fosphenytoin is a prodrug. It is converted rapidly (half-life15 minutes) to phenytoin. Fosphenytoin is less alkaline than phenytoin and can be

Cite this article. Fosphenytoin vs phenytoin for acute treatment of seizures. Pharmacoecon. Outcomes News 93, 8 (2024).

Fosphenytoin displaces phenytoin from protein binding sites. The volume of distribution of fosphenytoin increases with fosphenytoin sodium injection dose and rate, and ranges from 4.3 to 10.8 liters. Elimination. The conversion half-life of fosphenytoin to phenytoin is approximately 15 minutes. Metabolism