Drugs for brain tumor
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Several drugs have now been shown to extend patients' lives and improve the management of brain tumors. The Brain Tumor Center at Memorial Sloan Kettering is
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2. Challenges in developing drugs for brain cancer. Compared with peripheral tumors, the treatment of brain tumors faces many challenges (Figure 1).On the one hand, the physiological barriers (such as blood-brain barrier (BBB), blood-brain tumor barrier (BBTB)) and the over-expressed efflux pumps prevent drugs from entering the central nervous system (CNS) and reaching the tumor site.
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Brain cancer chemotherapy uses powerful drugs to target malignant tumors in the brain. All brain tumor chemotherapy has the same goalto destroy tumors.
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The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the BBB and, consequently, survival outcomes for malignant brain tumors
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Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, the membranes around the brain (meninges)
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Brain cancer chemotherapy uses powerful drugs to target malignant tumors in the brain. All brain tumor chemotherapy has the same goalto destroy tumors by
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Several drugs have now been shown to extend patients' lives and improve the management of brain tumors. The Brain Tumor Center at Memorial Sloan Kettering is
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2. Challenges in developing drugs for brain cancer. Compared with peripheral tumors, the treatment of brain tumors faces many challenges (Figure 1).On the one hand, the physiological barriers (such as blood-brain barrier (BBB), blood-brain tumor barrier (BBTB)) and the over-expressed efflux pumps prevent drugs from entering the central nervous system (CNS) and reaching the tumor site.
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2. Challenges in developing drugs for brain cancer. Compared with peripheral tumors, the treatment of brain tumors faces many challenges (Figure 1).On the one hand, the physiological barriers (such as blood-brain barrier (BBB), blood-brain tumor barrier (BBTB)) and the over-expressed efflux pumps prevent drugs from entering the central nervous system (CNS) and reaching the tumor site.
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