View all 694 medications that may interact with methotrexate; View methotrexate alcohol/food interactions (3) View methotrexate disease interactions (5) Most frequently checked interactions. View interaction reports for methotrexate and the medicines listed below. Major; Moderate; Minor; Unknown; Ambien (zolpidem) Aspirin Low Strength (aspirin)
Adderall (amphetamine / dextroamphetamine) Aspir 81 (aspirin) Aspirin Low Benlysta, Cimzia, aspirin, prednisone, amoxicillin, doxycycline, methotrexate
Methotrexate the toxicity of methotrexate may be enhanced by aspirin. The risk of toxicity is greater in people receiving higher doses of methotrexate (15 mg daily or more per week) and aspirin due to the decreased renal clearance of methotrexate. The use of concomitant use of aspirin with methotrexate above this dose is contraindicated.
Other medicines may interfere with methotrexate. A list of common medications which interact with methotrexate: Salicylates (Aspirin). NSAIDs (Motrin
A: Methotrexate can theoretically interact with anti-inflammatory drugs including aspirin. This is not a concern with the dosages of Methotrexate prescribed for
Aspirin and aspirin-like medications Cidofovir Methotrexate NSAIDs, medications for pain and inflammation, like ibuprofen or naproxen Pentoxifylline
METHOTREXATE- methotrexate injection, solution. Hospira, Inc Antifolate drugs (e.g, dapsone, pemetrexed, pyrimethamine and sulfonamides); : Aspirin
Q: Is it OK to continue to take anti-inflammatory drugs (NSAIDs) and aspirin whilst on Methotrexate? A: Methotrexate can theoretically interact with anti-
NSAIDs should not be used with high-dose methotrexate. Caution is advised if you also take aspirin. NSAIDs/aspirin may be used with low-dose methotrexate
And here's some research on aspirin and stroke treatment https://www.webmd.com/stroke/news/20000601/aspirin-after-stroke-helps-prevent-another#1