Changing from effexor to pristiq

The main difference between Pristiq (desvenlafaxine) and Effexor (venlafaxine) is that Pristiq is the active form of Effexor. Effexor contains

Now comes Pristiq (desvenlafaxine), spawn of Effexor (you guessed it, venlafaxine). This one's also a simple metabolic change, OH from O-methyl.

One significant difference between Effexor and Pristiq is that Pristiq is a metabolite of Effexor. This means that when Effexor is metabolized by the body, it is converted into Pristiq. Some individuals may find Pristiq to be better tolerated than Effexor due to its more uniform absorption profile.

Pristiq and Effexor are basically the same drug, although Pristiq is a concentrated version of Effexor, in other words Pristiq is stronger, and both drugs are difficult to withdrawal from. I think because you switched out 50mg of Pristiq for 37.5mg of Effexor is the reason you are having such difficultly (as well as the 50% reduction of Pristiq).

Now comes Pristiq (desvenlafaxine), spawn of Effexor (you guessed it, venlafaxine). This one's also a simple metabolic change, OH from O-methyl.

But I ended up changing to Effexor XR (it's metabolized partially into pristiq) high dose in the end. The pristiq was very tolerable but I didn't benefit from it that much. Effexor has been less energetic for sure but do far has worked better for me.

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One significant difference between Effexor and Pristiq is that Pristiq is a metabolite of Effexor. This means that when Effexor is metabolized by the body, it is converted into Pristiq. Some individuals may find Pristiq to be better tolerated than Effexor due to its more uniform absorption profile.