Comment
Author: Admin | 2025-04-28
In the terminal phase (t½β) averages about 14 hours following single doses; with multiple dosing, t½β reportedly averages 21 hours. Special PopulationsHepatic impairment can decrease elimination of bupropion. Renal impairment may decrease elimination of major metabolites. StabilityStorageOralConventional Bupropion Hydrochloride Tablets20–25°C in tight container; protect from light and moisture.Extended-release Bupropion Hydrochloride TabletsExtended-release (e.g., Wellbutrin SR): 20–25°C (excursions permitted to 15–30°C); protect from light and moisture. Extended-release tablets (Wellbutrin XL): 25°C (excursions permitted to 15–30°C).Extended-release 450-mg tablets (Forfivo XL): 20–25°C.Extended-release Bupropion Hydrobromide TabletsExtended-release tablets (Aplenzin): 25°C (excursions permitted to 15–30°C).ActionsChemically unrelated to tricyclic, tetracyclic, or other currently available antidepressants (e.g., SSRIs); also chemically unrelated to nicotine or other agents currently used in treatment of nicotine dependence.Mechanism of antidepressant action is unclear; noradrenergic and/or dopaminergic pathways appear to be principally involved. Relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine; does not inhibit monoamine oxidase or reuptake of serotonin. Mechanism of action as an adjunct in the cessation of smoking is unclear; noradrenergic and/or dopaminergic effects presumably are involved. Produces less frequent anticholinergic effects, cardiovascular effects, antihistaminic effects, and weight gain compared with tricyclic antidepressants at usual dosages. Advice to PatientsAdvise patients to swallow tablets whole and not to crush, chew, or divide the tablets. Advise patients to take conventional bupropion hydrochloride tablets in 3–4 divided doses daily, with ≥6 hours between subsequent doses.Instruct patients to take bupropion hydrochloride extended-release tablets in 2 divided doses, preferably with ≥8 hours between successive doses, when doses are >150 mg daily to minimize the risk of seizures. Instruct patients to take bupropion hydrochloride extended-release tablets (e.g., Wellbutrin XL) once daily in the morning.Instruct patients that if they miss a dose, they should not take an extra tablet to make up for the missed dose and should take the next tablet at the regular time
Add Comment