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Author: Admin | 2025-04-28
SubQ: 2.5 to 2.8 hoursSaizen: SubQ: ~2 hoursSerostim: SubQ: 4.28 ± 2.15 hoursZomacton: SubQ: ~2.7 hoursZorbtive: SubQ: 4 ± 2 hours Use in Specific PopulationsSpecial Populations: Renal Function ImpairmentPatients with chronic renal failure and ESRD have decreased clearance.Special Populations: Hepatic Function ImpairmentReduction in clearance has been noted in patients with severe hepatic impairment. Use: Labeled IndicationsGrowth failure (pediatric patients):Treatment of growth failure due to inadequate endogenous growth hormone secretion (Genotropin, Humatrope, Norditropin, Nutropin, Nutropin AQ, Omnitrope, Saizen, Tev-Tropin, Zomacton).Treatment of short stature associated with Turner syndrome (Genotropin, Humatrope, Norditropin, Nutropin, Nutropin AQ, Omnitrope, Zomacton).Treatment of Prader-Willi syndrome (Genotropin, Norditropin, Omnitrope).Treatment of growth failure associated with chronic kidney disease up until the time of renal transplantation (Nutropin, Nutropin AQ).Treatment of growth failure in children born small for gestational age who fail to manifest catch-up growth by 2 years of age (Genotropin, Omnitrope) or by 2 to 4 years of age (Humatrope, Norditropin, Zomacton)Treatment of idiopathic short stature (nongrowth hormone-deficient short stature), defined by height standard deviation score (SDS) ≤-2.25 and growth rate not likely to attain adult height in the normal range, in pediatric patients whose epiphyses are not closed and for whom other causes associated with short stature have been excluded (Genotropin, Humatrope, Norditropin, Nutropin, Nutropin AQ, Omnitrope, Zomacton).Treatment of short stature or growth failure associated with short stature homeobox gene (SHOX) deficiency (Humatrope, Zomacton).Treatment of short stature associated with Noonan syndrome (Norditropin)Growth hormone deficiency (adults): Replacement of endogenous growth hormone in adults with growth hormone deficiency who meet either of the following criteria (Genotropin, Humatrope, Norditropin, Nutropin, Nutropin AQ, Omnitrope, Saizen, Zomacton):Adult-onset: Patients who have adult growth hormone deficiency whether alone or with multiple hormone deficiencies (hypopituitarism) as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or traumaorChildhood-onset: Patients who were growth hormone deficient during childhood as a result of congenital, genetic, acquired, or idiopathic causes, confirmed as an adult before replacement therapy is initiatedHIV-associated wasting, cachexia: Treatment of HIV patients with wasting or cachexia (Serostim).Short bowel syndrome: Treatment of short-bowel syndrome in patients receiving specialized nutritional support (Zorbtive). Use: Off LabelHIV-associated adipose redistribution syndrome (HARS) (Serostim)bData
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