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Author: Admin | 2025-04-28
Formulations contain the active ingredient “diphenhydramine hydrochloride,” the primary ingredient in Benadryl. To learn how long Unisom sold outside of the United States stays in your system, simply reference the article, “How long does Benadryl stay in your system?”Source: https://pubchem.ncbi.nlm.nih.gov/compound/doxylamineSource: http://www.ncbi.nlm.nih.gov/pubmed/4056080Variables that influence how long Unisom stays in your systemThough we can estimate that Unisom manufactured in the United States is likely to remain in a user’s system for approximately 2.29 days after cessation, there is often interindividual variance in elimination speed. In other words, not everyone will eliminate the drug in precisely 2.29 days; some will be faster or slower than average in regards to excretion. The variance in interindividual excretion speed is a byproduct of variables such as: the specific person taking Unisom, dosage, frequency of administration, and whether other drugs were simultaneously administered.Individual factorsConsider the idea that two individuals could simultaneously ingest a single identical (6.25 mg) dosage of Unisom. Though each user may eliminate the drug in less than 3 days, one user may eliminate the drug in exactly 50 hours, yet the other person may eliminate it from his/her system in 60 hours. Assuming equal-strength single doses were ingested simultaneously, the 10 hour difference in elimination speed can usually be explained by individual factors.Age + Sex: One study compared the pharmacokinetics of doxylamine succinate among young adults (ages 20 to 43) to that among elderly (ages 60 to 87). Single oral doses of 25 mg were administered to each of the participants and researchers took note of pharmacokinetic differences. It appeared as though elderly men exhibited reduced doxylamine clearance and a prolonged half-life compared to young adults and elderly women.The half-life of doxylamine succinate among elderly men increased by approximately 5.3 hours to 15.5 hours. This suggests that elderly men may take 3.55 days to eliminate the drug from their system, compared to less than 2.5 days for elderly women and young adults. Though the exact reason for which Unisom is likely to remain in the system of elderly men for a longer duration isn’t well known, it is speculatively associated with reduced efficiency of
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