Comment
Author: Admin | 2025-04-28
And effectiveness Peak concentrations of amitriptyline are reached within 4 to 8 hours. Amitriptyline is metabolized to an active metabolite (nortriptyline) so the effects of amitriptyline are long-lasting. The antidepressant effect may take several weeks to develop. 7. Interactions Medicines that interact with amitriptyline may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with amitriptyline. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Common medications that may interact with amitriptyline include:anticoagulants (blood thinners), such as warfarin, or other drugs that have blood-thinning effects such as aspirin or NSAIDsanticonvulsants, such as phenytoin, phenobarbital, or primidoneantipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, olanzapine, quetiapine, ziprasidone)any medication that may cause drowsiness, such as benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as codeine, morphine)aspirinbupropionbuspironecimetidinecisapridediuretics, such as furosemidedisulfiramipratropiumlithiummedications that may affect the heartbeat by prolonging the QT interval, such as amiodarone, encainide, flecainide, or pimozide medications that induce or inhibit CYP2D6 such as amiodarone, bupropion, or duloxetineother antidepressants, such as tricyclic antidepressants (eg, clomipramine), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), venlafaxine, and SSRIs (eg, paroxetine, sertraline)other medications that affect serotonin, such as amphetamines, fentanyl, lithium, tramadol, triptans (eg, almotriptan, eletriptan, or sumatriptan), or St. John's Wort others, such as HIV medications (fosamprenavir, ritonavir), fluconazole, or procyclidinetopiramate.May enhance the effects of alcohol and the effects of other CNS depressants. Avoid drinking alcohol or taking illegal or recreational drugs while taking amitriptyline.Note that this list is not all-inclusive and includes only common medications that may interact with amitriptyline. You should refer to the prescribing information for amitriptyline for a complete list of interactions. Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amitriptyline only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2025 Drugs.com. Revision date: October 3, 2023.Medical Disclaimer
Add Comment