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Author: Admin | 2025-04-28
Water intoxicationComments:Dose is determined by uterine response and therefore should be individualized; dosage information is based upon various regimens that have been used.Uses: Treatment of incomplete, inevitable, or elective abortion.Renal Dose AdjustmentsUse cautionLiver Dose AdjustmentsUse cautionPrecautionsUS BOXED WARNING:Elective induction of labor is defined as the initiation of labor in a pregnant individual who has no medical indications for induction. Since the available data are inadequate to evaluate the benefits-to-risks considerations, this drug is not indicated for elective induction of labor.CONTRAINDICATIONS:Hypersensitivity to the active substanceSignificant cephalopelvic disproportionUnfavorable fetal positions or presentations, such as transverse lies, which are undeliverable without conversion prior to deliveryObstetrical emergencies where the benefit-to-risk ratio for either the fetus or the mother favors surgical interventionFetal distress where delivery is not imminentProlonged use in uterine inertia or severe toxemiaHyperactive or hypertonic uterusIn cases where vaginal delivery is contraindicated, such as invasive cervical carcinoma, active herpes genitalis, total placenta previa, vasa previa, and cord presentation or prolapse of the cordSafety and efficacy have not been established in patients younger than 18 years.Consult WARNINGS section for additional precautions.DialysisData not availableOther CommentsAdministration advice:For Induction of Labor or Augmentation of Uterine Activity:IV infusion via an infusion pump to ensure accurate control of the infusion rateControl of Postpartum Uterine Bleeding:IV infusion or IM injection after delivery of the placentaTreatment of Incomplete, Inevitable, or elective Abortion:IV infusionStorage requirements:Store between 20C and 25C (68F to 77F); do not freezeReconstitution/preparation techniques:1000 milliunits is equivalent to 1 unitStandard solution for infusion of oxytocin for induction/augmentation of labor is 10 milliunits of oxytocin/mL; this can be prepared by adding 10 units of oxytocin to 1000 mL infusion bag of 0.9% sodium chloride or Ringer's lactateMaximum concentration recommended to control postpartum uterine bleeding is 40 units/1000 mLAvailable in prepared infusion bags with 0.9% normal saline, dextrose, or lactated ringersGeneral:For induction of labor or augmentation of uterine activity, this drug should be administered by IV infusion with adequate medical supervision in a hospital setting.Monitoring:Uterine activity and fetal heart rate monitoring should be performed throughout the infusion; attention should be given to tonus, amplitude, and frequency of contractions, and to the fetal heart rate in relation to uterine contractionsFurther informationAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Medical Disclaimer
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