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Author: Admin | 2025-04-28
May increase your risk for more severe constipation and constipation-related complications. Discuss this with your doctor.Which CGRP inhibitors cause constipation?Not all CGRP inhibitors have been associated with constipation. There are three other FDA-approved CGRP inhibitors, including:Ajovy (fremanezumab-vfrm)Emgality (galcanezumab-gnlm)Vyepti (eptinezumab-jjmr)According to the manufacturer’s data, none of these agents have been linked with constipation. Ajovy, Emgality and Vyepti bind to the CGRP ligand and block CGRP from binding to the receptor, while Aimovig binds to and blocks the actual CGRP receptor site.However, the constipation due to Aimovig was reported post-marketing (after the drug was approved). It is not known if post-marketing reports will eventually link the other CGRP agents with constipation.Related questionsWhat are the new drugs for the treatment of migraine?Ajovy vs Aimovig: What's the difference between them?How long does Aimovig last in your system?What other side effects occur with Aimovig treatment?Beside constipation, other common side effects with Aimovig include injection site reactions (pain, redness, or swelling).Aimovig can also cause serious allergies, high blood pressure or worsening of high blood pressure, and cramps and muscle spasms.Call your health care provider or get emergency medical help right away if you experience:swelling of the face, mouth, tongue, or throathave trouble breathing.These are all signs of a possible allergic reaction.See also:Aimovig side effects (in more detail)These are not all the possible side effects of Aimovig. For more information, ask your doctor, nurse or pharmacist.Bottom LineSome research suggests that CGRP may play an important role in maintaining the movement of the bowels.Blocking intestinal CGRP with a
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