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Author: Admin | 2025-04-28
In our latest question and answer, the pharmacist discusses how long it takes for Medrol (methylprednisolone) to start working. Question I just started a Medrol Dose Pack. I have taken it in the past. How long does it take to know that it's working? Asked by Joanne On Dec 14, 2021 Published Dec 14, 2021 Last updated Mar 02, 2025 Key points Medrol (methylprednisolone) is absorbed quickly after taking by mouth, reaching peak concentrations in 1-2 hours. It may take longer to notice the effects of the drug, however. If you are treating something like contact dermatitis (i.e. a skin rash caused by something like poison ivy), it should begin to help relieve your itching and rash within a 12 to 24 hours. If you are treating other conditions, like pain, it may take a day or two for you to notice the effects. Thanks for reaching out to us!How soon you will start to feel your Medrol Dose Pack (methylprednisolone) working depends both on the individual taking it and what exactly you are taking it for.For example, if you are taking it for the treatment of pain, say, low back or joint pain, it might take a few days to begin to notice the effects as inflammation subsides.If you are taking it for the treatment of contact dermatitis, like poison ivy, you most likely will begin to feel better much faster, within 12 to 24 hours.From a pharmacokinetic standpoint, which relates to measurable characteristics of drugs such as their absorption, distribution, and metabolism, methylprednisolone (the oral tablet form) is a fast-acting drug. After taking it by mouth, it is rapidly absorbed and peak concentrations in the blood are reached within 1-2 hours.However, just because it is absorbed from the GI tract and reaches the bloodstream quickly, this doesn't necessarily mean you'll notice the effects that fast.I discuss the onset of action of Medrol in more detail below in the next section.Onset Of ActionThere have been numerous studies evaluating the effects of methylprednisolone (or similar systemic steroids) for the treatment of a variety of indications, including acute back pain, bronchitis,
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