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Author: Admin | 2025-04-28
Medical DisclaimerThe medications listed on this website are provided for informational purposes only. Their inclusion does not guarantee that they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. This list is not exhaustive, and healthcare providers may prescribe other medications, including non-stimulant options, based on the patient’s unique health circumstances and needs.Read more Bupropion, commonly known under its brand name Wellbutrin, is an antidepressant medication. The FDA has authorized it as a treatment for depression and seasonal affective disorder. It can also be prescribed as a smoking cessation aid under the brand name Zyban [1*] .Even though Wellbutrin has proven efficacy [2*] , it may not work the same for all patients. Several signals can help understand whether Wellbutrin is functioning or not. Read on to learn more about these signs that can prepare you for an informed discussion with a doctor during follow-up appointments.Consult licensed mental health professionals online to get a personalized treatment plan. How Does Wellbutrin Work? Wellbutrin is classified as a norepinephrine-dopamine reuptake inhibitor (NDRI). Its exact mechanism of action is yet unknown. Researchers [3*] think it interferes with the reuptake of two neurotransmitters: dopamine and norepinephrine (although the inhibition is weak compared to other antidepressants). These neurotransmitters play crucial roles in regulating mood, attention, and pleasure. However, Bupropion does not affect serotonin reuptake or the blocking of monoamine oxidase, two important enzymes in the brain.As a result of its ability to boost dopamine levels in the brain, Bupropion can effectively treat depressive disorders by improving mood and alleviating the nicotine withdrawal-induced dopamine deficit. After entering the body, the medication is broken down into three distinct metabolites, each of which has a separate effect on the body, which accounts for its efficacy. What is Wellbutrin SR? Wellbutrin is available in different formulations, such as Wellbutrin SR and Wellbutrin XL. The SR in the former one stands for sustained-release while the latter one is an extended-release medicine. With Wellbutrin SR, bupropion is slowly released into the bloodstream over a longer period, typically around 12 hours, which helps minimize
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